HydrogenEZE
Molecular Hydrogen is at the leading edge of medical gas research investigating cutting edge scientific solutions to oxidative stress and its impact on chronic degenerative diseases, accelerated ageing, and acid-base related diseases. Molecular Hydrogen in gaseous form and water enriched with hydrogen gas have been studied at major research institutions as a treatment for neurodegenerative conditions, psychosis, cancer, inflammatory and allergic conditions. Research is focusing on Hydrogen’s selective antioxidant action, anti-inflammatory, anti-acid, and epigenetic signalling functions.
HydrogenEZE is a patented formula created by Dr. Dusan Miljkovic. Dr Miljkovic is a veteran scientist with a PhD in Chemistry and over 30 years research and development experience in the pharmaceutical industry with over 15 patents. HydrogenEZE is a unique and ultra pure metallic stabilized magnesium and mineral formula. When ingested it creates a reaction releasing trillions of negatively charged microscopic bubbles of Hydrogen. Due to its extremely small size (2.4 Angstroms) .24 nanometre (0.24 Trillionth of a Meter), these microscopic bubbles spread throughout the body in seconds penetrating all tissue, cells, and cell components providing rapid protection from free radical damage. Research finding indicate that molecular hydrogen’s antioxidant function is selective. It selectively eliminates the more destructive free radicals such as peroxynitrites and hydroxyl radicals and not as much the Super Oxide and Hydrogen Peroxide which are used by our immune system to defend against microbial pathogens.
This is a very useful function as the internal defence systems such as Super Oxide Dismutase (SOD) and Catalase are not capable of neutralizing the peroxynitrites and hydroxyl radicals. While intracellular defence systems such as the internal antioxidants and antioxidant enzyme systems can protect internal cellular components, Recovery Hydro FX not only has the capacity to protect intracellular environments and cellular components including the internal antioxidant enzymes such SOD, Catalase and peptide antioxidants such as Glutathione but may also be involved in their epigenetic induction and up-regulation via nrf-2 pathway. Since all cellular constituents are made with proteins, lipids, carbohydrates, DNA, RNA, and vitamins, and minerals, these can be oxidized. The oxidation can arise from not only from internally generated free radicals but also from the toxic load of environmental chemicals we absorb from the environment via air, water, food, and skin/hair products. Molecular Hydrogen released from Recovery with HydroFx can be used effectively to reduce the damage. Due to HydrogenEZE's nature (low concentration of magnesium), it is safe to be taken by children, pregnant and lactating women, elderly, and those on medications. It is a unique and powerful formula that can be used in conjunction with any other treatment natural or allopathic.
Why is hydrogen generated by HydogenEZE so effective?
- Selective antioxidant function: Eliminates the more destructive peroxynitrite and hydroxyl free radicals.
- Extremely high number of negative charges (electron donating). The negatively charged bubbles of Molecular Hydrogen carries a cluster of electrons which are free to be donated to free radicals. (Ref. Communications with Dr Dusan Milkjovic, PhD -Inventor)
- Size (smallest atom). Due to the extremely small size, molecular hydrogen can penetrate all cellular components and available both in intra- cellular and extra-cellular matrices.
- Rapid mobility due to gaseous nature (high collision and reaction rates with free radicals) makes it a effective antioxidant
- Function as a messenger molecule and transcription factor (potential nrf-2 activator)
- Function as signalling molecules in modulating pathways involved in inflammation and allergies (TNF alpha, NFkappa..)
- Acid neutralizing effect (i.e. Lactic acid) and therefore supports acid alkaline balance in the body.
- Anti-Apoptosis Reduction in pre-mature cell death.
As Health Professionals we have a wonderful opportunity in this period of time to help not only ourselves but our clients using this scientifically validated cutting edge formula. Having trialled it for over 5 years on myself, family, friends, and clients as well as assessing in my practice, blood samples of clients before and after ingesting 3 capsules using dark-field microscopy, I have full confidence in the formula that it can truly
revolutionise health with its broad spectrum therapeutic functionality.
For research studies on Molecular Hydrogen:
http://www.molecularhydrogenstudies.com/
Dr. Ranga J. Premaratna PhD
(Food and Nutritional Scientist and Ayurvedic Consultant)
Return To Wellness Clinic (At World of Health Shop)
Shop 8, 1-3, Brady St, Bridgepoint Shopping Centre,
Mosman, NSW Australia 2088
Tel: 61 2 9969 3920
Em: www.drrangawellness.com
References
- G. V. Buxton, C. L. Greenstock, W. P. Helman, and A. B. Ross, “Critical view of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (•OH/•OH−) in aqueous solution,” Journal of Physical and Chemical Reference Data, vol. 17, pp. 513–886, 1988.
- Y. Chuai, F. Gao, B. Li, et al., “Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals,” Biochemical Journal, vol. 442, pp. 49–56, 2012.
- V. Lafay, P. Barthelemy, B. Comet, Y. Frances, and Y. Jammes, “ECG changes during the experimental human dive HYDRA 10 (71 atm/7,200 kPa),” Undersea & Hyperbaric Medicine, vol. 22, no. 1, pp. 51–60, 1995. View at Scopus
- B. Gharib, S. Hanna, O. M. S. Abdallahi, H. Lepidi, B. Gardette, and M. De Reggi, “Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation,” Comptes Rendus de l'Academie des Sciences—Serie III, vol. 324, no. 8, pp. 719–724, 2001. View at Publisher · View at Google Scholar · View at Scopus
- K. I. Fukuda, S. Asoh, M. Ishikawa, Y. Yamamoto, I. Ohsawa, and S. Ohta, “Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress,” Biochemical and Biophysical Research Communications, vol. 361, no. 3, pp. 670–674, 2007. View at Publisher · View at Google Scholar · View at Scopus
- I. Ohsawa, M. Ishikawa, K. Takahashi et al., “Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals,” Nature Medicine, vol. 13, no. 6, pp. 688–694, 2007. View at Publisher · View at Google Scholar · View at Scopus
- C. S. Huang, T. Kawamura, Y. Toyoda, and A. Nakao, “Recent advances in hydrogen research as a therapeutic medical gas,” Free Radical Research, vol. 44, no. 9, pp. 971–982, 2010. View at Publisher · View at Google Scholar · View at Scopus
- S. Ohta, “Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications,” Current Pharmaceutical Design, vol. 17, pp. 2241–2252, 2011.
- G. A. Matchett, N. Fathali, Y. Hasegawa et al., “Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models,” Brain Research, vol. 1259, pp. 90–97, 2009. View at Publisher · View at Google Scholar · View at Scopus
- J. Cai, Z. Kang, W. W. Liu et al., “Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model,” Neuroscience Letters, vol. 441, no. 2, pp. 167–172, 2008. View at Publisher ·View at Google Scholar · View at Scopus
- F. Domoki, O. Oláh, A. Zimmermann et al., “Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs,” Pediatric Research, vol. 68, no. 5, pp. 387–392, 2010. View at Publisher · View at Google Scholar · View at Scopus
- J. M. Cai, Z. Kang, K. Liu et al., “Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model,” Brain Research, vol. 1256, pp. 129–137, 2009. View at Publisher · View at Google Scholar · View at Scopus
- R. Fujita, Y. Tanaka, Y. Saihara, et al., “Effect of molecular hydrogen saturated alkaline electrolyzed water on disuse muscle atrophy in gastrocnemius muscle,” Journal of Physiological Anthropology, vol. 30, pp. 195–201, 2011.
- Y. Saitoh, H. Okayasu, L. Xiao, Y. Harata, and N. Miwa, “Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression,” Oncology Research, vol. 17, no. 6, pp. 247–255, 2008. View at Publisher · View at Google Scholar · View at Scopus
- J. Ye, Y. Li, T. Hamasaki et al., “Inhibitory effect of electrolyzed reduced water on tumor angiogenesis,” Biological and Pharmaceutical Bulletin, vol. 31, no. 1, pp. 19–26, 2008. View at Publisher · View at Google Scholar · View at Scopus
- L. Zhao, C. Zhou, J. Zhang et al., “Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice,” International Journal of Biological Sciences, vol. 7, no. 3, pp. 297–300, 2011. View at Scopus
- A. H. Schapira, “Mitochondria in the aetiology and pathogenesis of Parkinson's disease,” The Lancet Neurology, vol. 7, no. 1, pp. 97–109, 2008. View at Publisher · View at Google Scholar ·View at Scopus
- Y. Fu, M. Ito, Y. Fujita et al., “Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease,” Neuroscience Letters, vol. 453, no. 2, pp. 81–85, 2009. View at Publisher · View at Google Scholar · View at Scopus
- K. Fujita, T. Seike, N. Yutsudo et al., “Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease,” PLoS ONE, vol. 4, no. 9, Article ID e7247, 2009. View at Publisher · View at Google Scholar · View at Scopus
- M. Nakayama, H. Nakano, H. Hamada, N. Itami, R. Nakazawa, and S. Ito, “A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial,” Nephrology Dialysis Transplantation, vol. 25, no. 9, pp. 3026–3033, 2010. View at Publisher· View at Google Scholar · View at Scopus
- M. Jucker and L. C. Walker, “Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders,” Annals of Neurology, vol. 70, pp. 532–540, 2011.
- K. Nagata, N. Nakashima-Kamimura, T. Mikami, I. Ohsawa, and S. Ohta, “Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice,” Neuropsychopharmacology, vol. 34, no. 2, pp. 501–508, 2009. View at Publisher · View at Google Scholar · View at Scopus
- J. Li, C. Wang, J. H. Zhang, J. M. Cai, Y. P. Cao, and X. J. Sun, “Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress,” Brain Research, vol. 1328, pp. 152–161, 2010. View at Publisher · View at Google Scholar · View at Scopus
- C. Wang, J. Li, Q. Liu et al., “Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease,” Neuroscience Letters, vol. 491, no. 2, pp. 127–132, 2011. View at Publisher · View at Google Scholar · View at Scopus
- Y. Gu, C. S. Huang, T. Inoue et al., “Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice,” Journal of Clinical Biochemistry and Nutrition, vol. 46, no. 3, pp. 269–276, 2010. View at Publisher · View at Google Scholar · View at Scopus
- S. Kajiyama, G. Hasegawa, M. Asano et al., “Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance,”Nutrition Research, vol. 28, no. 3, pp. 137–143, 2008. View at Publisher · View at Google Scholar ·View at Scopus
- A. Nakao, Y. Toyoda, P. Sharma, M. Evans, and N. Guthrie, “Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome—an open label pilot study,”Journal of Clinical Biochemistry and Nutrition, vol. 46, no. 2, pp. 140–149, 2010. View at Publisher · View at Google Scholar · View at Scopus
- M. Nakayama, S. Kabayama, H. Nakano et al., “Biological effects of electrolyzed water in hemodialysis,” Nephron, vol. 112, no. 1, pp. C9–C15, 2009. View at Publisher · View at Google Scholar · View at Scopus
- M. Ito, T. Ibi, K. Sahashi, M. Ichihara, and K. Ohno, “Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies,” Medical Gas Research, vol. 1, article 24, 2011.
- H. Ono, Y. Nishijima, N. Adachi, et al., “Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study,” Medical Gas Research, vol. 1, article 12, 2011. View at Publisher · View at Google Scholar
- K. M. Kang, Y. N. Kang, I. B. Choi, et al., “Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors,” Medical Gas Research, vol. 1, article 11, 2011.
- Y. Li, T. Hamasaki, N. Nakamichi et al., “Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus,” Cytotechnology, vol. 63, no. 2, pp. 119–131, 2011. View at Publisher · View at Google Scholar · View at Scopus
- N. Kamimura, K. Nishimaki, I. Ohsawa, and S. Ohta, “Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice,” Obesity, vol. 19, no. 7, pp. 1396–1403, 2011. View at Publisher · View at Google Scholar · View at Scopus
- C. H. Chen, A. Manaenko, Y. Zhan et al., “Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model,” Neuroscience, vol. 169, no. 1, pp. 402–414, 2010. View at Publisher · View at Google Scholar · View at Scopus
- P. Yu, Z. Wang, X. Sun et al., “Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage,” Biochemical and Biophysical Research Communications, vol. 409, no. 2, pp. 350–355, 2011. View at Publisher · View at Google Scholar ·View at Scopus
- Y. Zhang, Q. Sun, B. He, J. Xiao, Z. Wang, and X. Sun, “Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion,” International Journal of Cardiology, vol. 148, no. 1, pp. 91–95, 2011. View at Publisher · View at Google Scholar · View at Scopus
- W. J. Zhu, M. Nakayama, T. Mori et al., “Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats,” Nephrology Dialysis Transplantation, vol. 26, no. 7, pp. 2112–2118, 2011. View at Publisher · View at Google Scholar · View at Scopus
- T. Hanaoka, N. Kamimura, T. Yokota, S. Takai, and S. Ohta, “Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide,” Medical Gas Research, vol. 1, article 18, 2011.
- D. D. Thomas, L. A. Ridnour, J. S. Isenberg et al., “The chemical biology of nitric oxide: implications in cellular signaling,” Free Radical Biology and Medicine, vol. 45, no. 1, pp. 18–31, 2008. View at Publisher · View at Google Scholar · View at Scopus
- Y. Nakai, B. Sato, S. Ushiama, S. Okada, K. Abe, and S. Arai, “Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water,” Bioscience, Biotechnology and Biochemistry, vol. 75, no. 4, pp. 774–776, 2011. View at Publisher · View at Google Scholar · View at Scopus
- B. M. Buchholz, D. J. Kaczorowski, R. Sugimoto et al., “Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury,” American Journal of Transplantation, vol. 8, no. 10, pp. 2015–2024, 2008. View at Publisher · View at Google Scholar ·View at Scopus
- M. Kajiya, M. J. B. Silva, K. Sato, K. Ouhara, and T. Kawai, “Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate,” Biochemical and Biophysical Research Communications, vol. 386, no. 1, pp. 11–15, 2009. View at Publisher · View at Google Scholar ·View at Scopus
- M. Kajiya, K. Sato, M. J. B. Silva et al., “Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis,” Biochemical and Biophysical Research Communications, vol. 386, no. 2, pp. 316–321, 2009. View at Publisher · View at Google Scholar · View at Scopus
- Y. F. Mao, X. F. Zheng, J. M. Cai et al., “Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats,” Biochemical and Biophysical Research Communications, vol. 381, no. 4, pp. 602–605, 2009. View at Publisher · View at Google Scholar · View at Scopus
- X. Zheng, Y. Mao, J. Cai et al., “Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats,” Free Radical Research, vol. 43, no. 5, pp. 478–484, 2009.View at Publisher · View at Google Scholar · View at Scopus
- A. Nakao, D. J. Kaczorowski, Y. Wang et al., “Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both,” Journal of Heart and Lung Transplantation, vol. 29, no. 5, pp. 544–553, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Q. Liu, W. F. Shen, H. Y. Sun et al., “Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice,” Liver International, vol. 30, no. 7, pp. 958–968, 2010. View at Publisher ·View at Google Scholar · View at Scopus
- T. Hayashi, T. Yoshioka, K. Hasegawa, et al., “Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice,” American Journal of Physiology, vol. 301, pp. H1062–H1069, 2011.
- K. S. Yoon, X. Z. Huang, Y. S. Yoon, et al., “Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice,” Biological and Pharmaceutical Bulletin, vol. 34, pp. 1671–1677, 2011.
- G. Song, H. Tian, J. Liu, H. Zhang, X. Sun, and S. Qin, “H2 inhibits TNF-α-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor κB activation in endothelial cells,” Biotechnology Letters, vol. 33, no. 9, pp. 1715–1722, 2011. View at Publisher · View at Google Scholar · View at Scopus
- Y. Huang, K. Xie, J. Li et al., “Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits,” Brain Research, vol. 1378, pp. 125–136, 2011. View at Publisher ·View at Google Scholar · View at Scopus
- Q. Sun, J. Cai, J. Zhou et al., “Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity,” Critical Care Medicine, vol. 39, no. 4, pp. 765–769, 2011. View at Publisher · View at Google Scholar · View at Scopus
- Q. A. Sun, J. Cai, S. Liu et al., “Hydrogen-rich saline provides protection against hyperoxic lung injury,” Journal of Surgical Research, vol. 165, no. 1, pp. e43–e49, 2011. View at Publisher · View at Google Scholar · View at Scopus
- F. Wang, G. Yu, S. Y. Liu et al., “Hydrogen-rich saline protects against renal ischemia/reperfusion injury in rats,” Journal of Surgical Research, vol. 167, no. 2, pp. e339–e344, 2011. View at Publisher · View at Google Scholar · View at Scopus
- Q. Ji, K. Hui, L. Zhang, X. Sun, W. Li, and M. Duan, “The effect of hydrogen-rich saline on the brain of rats with transient ischemia,” Journal of Surgical Research, vol. 168, no. 1, pp. e95–e101, 2011. View at Publisher · View at Google Scholar · View at Scopus
- Y. Liu, W. Liu, X. Sun, et al., “Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model,” Medical Gas Research, vol. 1, article 15, 2011.
- L. Shen, J. Wang, K. Liu et al., “Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest,” Neurochemical Research, vol. 36, no. 8, pp. 1501–1511, 2011.View at Publisher · View at Google Scholar · View at Scopus
- X. Yang, L. Guo, X. Sun, X. Chen, and X. Tong, “Protective effects of hydrogen-rich saline in preeclampsia rat model,” Placenta, vol. 32, pp. 681–686, 2011. View at Publisher · View at Google Scholar · View at Scopus
- B. M. Buchholz, K. Masutani, T. Kawamura, et al., “Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation,”Transplantation, vol. 92, pp. 985–992, 2011.
- C. S. Huang, T. Kawamura, X. Peng et al., “Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation,”Biochemical and Biophysical Research Communications, vol. 408, no. 2, pp. 253–258, 2011. View at Publisher · View at Google Scholar · View at Scopus
- M. Kubota, S. Shimmura, S. Kubota et al., “Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model,” Investigative Ophthalmology and Visual Science, vol. 52, no. 1, pp. 427–433, 2011. View at Publisher · View at Google Scholar ·View at Scopus
- H. Sun, L. Chen, W. Zhou et al., “The protective role of hydrogen-rich saline in experimental liver injury in mice,” Journal of Hepatology, vol. 54, no. 3, pp. 471–480, 2011. View at Publisher · View at Google Scholar · View at Scopus
- H. Chen, Y. P. Sun, P. F. Hu et al., “The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats,” Journal of Surgical Research, vol. 167, no. 2, pp. 316–322, 2011. View at Publisher · View at Google Scholar · View at Scopus
- T. Itoh, Y. Fujita, M. Ito et al., “Molecular hydrogen suppresses FcεRI-mediated signal transduction and prevents degranulation of mast cells,” Biochemical and Biophysical Research Communications, vol. 389, no. 4, pp. 651–656, 2009. View at Publisher · View at Google Scholar ·View at Scopus
- Q. Sun, Z. Kang, J. Cai et al., “Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats,” Experimental Biology and Medicine, vol. 234, no. 10, pp. 1212–1219, 2009. View at Publisher · View at Google Scholar · View at Scopus
- M. Hugyecz, É. Mracskó, P. Hertelendy, E. Farkas, F. Domoki, and F. Bari, “Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus,” Brain Research, vol. 1404, pp. 31–38, 2011. View at Publisher · View at Google Scholar · View at Scopus
- T. Itoh, N. Hamada, R. Terazawa et al., “Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages,” Biochemical and Biophysical Research Communications, vol. 411, no. 1, pp. 143–149, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. U. Christl, P. R. Murgatroyd, G. R. Gibson, and J. H. Cummings, “Production, metabolism, and excretion of hydrogen in the large intestine,” Gastroenterology, vol. 102, no. 4, pp. 1269–1277, 1992. View at Scopus
- A. Strocchi and M. D. Levitt, “Maintaining intestinal H2 balance: credit the colonic bacteria,”Gastroenterology, vol. 102, no. 4, pp. 1424–1426, 1992. View at Scopus
- Y. Suzuki, M. Sano, K. Hayashida, I. Ohsawa, S. Ohta, and K. Fukuda, “Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?” FEBS Letters, vol. 583, no. 13, pp. 2157–2159, 2009. View at Publisher ·View at Google Scholar · View at Scopus
- A. Shimouchi, K. Nose, M. Takaoka, H. Hayashi, and T. Kondo, “Effect of dietary turmeric on breath hydrogen,” Digestive Diseases and Sciences, vol. 54, no. 8, pp. 1725–1729, 2009. View at Publisher · View at Google Scholar · View at Scopus
- G. R. Corazza, M. Sorge, A. Strocchi et al., “Non-absorbable antibiotics and small bowel bacterial overgrowth,” Italian Journal of Gastroenterology, vol. 24, no. 9, pp. 4–9, 1992. View at Scopus
- X. Chen, Q. Zuo, Y. Hai, and X. J. Sun, “Lactulose: an indirect antioxidant ameliorating inflammatory bowel disease by increasing hydrogen production,” Medical Hypotheses, vol. 76, no. 3, pp. 325–327, 2011. View at Publisher · View at Google Scholar · View at Scopus
- M. Ito, M. Hirayama, K. Yamai, et al., “Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats,” Medical Gas Research, vol. 2, article 15, 2012.
- Y. Sato, S. Kajiyama, A. Amano et al., “Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice,” Biochemical and Biophysical Research Communications, vol. 375, no. 3, pp. 346–350, 2008. View at Publisher · View at Google Scholar · View at Scopus
- X. Ji, W. Liu, K. Xie et al., “Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress,” Brain Research, vol. 1354, pp. 196–205, 2010. View at Publisher · View at Google Scholar · View at Scopus
- J. M. Eckermann, W. Chen, V. Jadhav, et al., “Hydrogen is neuroprotective against surgically induced brain injury,” Medical Gas Research, vol. 1, article 7, 2011.
- C. Chen, Q. Chen, Y. Mao et al., “Hydrogen-rich saline protects against spinal cord injury in rats,”Neurochemical Research, vol. 35, no. 7, pp. 1111–1118, 2010. View at Publisher · View at Google Scholar · View at Scopus
- H. Oharazawa, T. Igarashi, T. Yokota et al., “Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury,”Investigative Ophthalmology and Visual Science, vol. 51, no. 1, pp. 487–492, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Y. S. Kikkawa, T. Nakagawa, R. T. Horie, and J. Ito, “Hydrogen protects auditory hair cells from free radicals,” NeuroReport, vol. 20, no. 7, pp. 689–694, 2009. View at Publisher · View at Google Scholar · View at Scopus
- A. Taura, Y. S. Kikkawa, T. Nakagawa, and J. Ito, “Hydrogen protects vestibular hair cells from free radicals,” Acta Oto-Laryngologica, vol. 130, no. 563, pp. 95–100, 2010. View at Publisher ·View at Google Scholar · View at Scopus
- Y. Lin, A. Kashio, T. Sakamoto, K. Suzukawa, A. Kakigi, and T. Yamasoba, “Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs,” Neuroscience Letters, vol. 487, no. 1, pp. 12–16, 2011. View at Publisher · View at Google Scholar · View at Scopus
- J. Zheng, K. Liu, Z. Kang et al., “Saturated hydrogen saline protects the lung against oxygen toxicity,” Undersea and Hyperbaric Medicine, vol. 37, no. 3, pp. 185–192, 2010. View at Scopus
- C. S. Huang, T. Kawamura, S. Lee et al., “Hydrogen inhalation ameliorates ventilator-induced lung injury,” Critical Care, vol. 14, no. 6, article R234, 2010. View at Publisher · View at Google Scholar · View at Scopus
- T. Kawamura, C. S. Huang, N. Tochigi et al., “Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats,” Transplantation, vol. 90, no. 12, pp. 1344–1351, 2010. View at Publisher · View at Google Scholar · View at Scopus
- S. Liu, K. Liu, Q. Sun et al., “Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 305086, 7 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
- L. Qian, F. Cao, J. Cui et al., “The potential cardioprotective effects of hydrogenin irradiated mice,” Journal of Radiation Research, vol. 51, no. 6, pp. 741–747, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Y. Terasaki, I. Ohsawa, M. Terasaki, et al., “Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress,” American Journal of Physiology, vol. 301, pp. L415–L426, 2011.
- Y. Chuai, L. Zhao, J. Ni et al., “A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution,” Medical Science Monitor, vol. 17, no. 4, pp. 1–4, 2011. View at Scopus
- Y. Fang, X. J. Fu, C. Gu et al., “Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model,” Journal of Burn Care and Research, vol. 32, no. 3, pp. e82–e91, 2011.View at Publisher · View at Google Scholar · View at Scopus
- K. Hayashida, M. Sano, I. Ohsawa et al., “Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury,” Biochemical and Biophysical Research Communications, vol. 373, no. 1, pp. 30–35, 2008. View at Publisher · View at Google Scholar ·View at Scopus
- N. Nakashima-Kamimura, T. Mori, I. Ohsawa, S. Asoh, and S. Ohta, “Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice,” Cancer Chemotherapy and Pharmacology, vol. 64, no. 4, pp. 753–761, 2009. View at Publisher · View at Google Scholar · View at Scopus
- A. Kitamura, S. Kobayashi, T. Matsushita, H. Fujinawa, and K. Murase, “Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT,” British Journal of Radiology, vol. 83, no. 990, pp. 509–514, 2010.View at Publisher · View at Google Scholar · View at Scopus
- T. Matsushita, Y. Kusakabe, A. Kitamura, S. Okada, and K. Murase, “Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging,” Japanese Journal of Radiology, vol. 29, pp. 503–512, 2011.
- J. S. Cardinal, J. Zhan, Y. Wang et al., “Oral hydrogen water prevents chronic allograft nephropathy in rats,” Kidney International, vol. 77, no. 2, pp. 101–109, 2010. View at Publisher ·View at Google Scholar · View at Scopus
- Y. S. Yoon, D. H. Kim, S. K. Kim et al., “The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice,” Food and Chemical Toxicology, vol. 49, no. 8, pp. 1814–1819, 2011.View at Publisher · View at Google Scholar · View at Scopus
- H. Chen, Y. P. Sun, Y. Li et al., “Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats,” Biochemical and Biophysical Research Communications, vol. 393, no. 2, pp. 308–313, 2010. View at Publisher · View at Google Scholar · View at Scopus
- I. Ohsawa, K. Nishimaki, K. Yamagata, M. Ishikawa, and S. Ohta, “Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice,” Biochemical and Biophysical Research Communications, vol. 377, no. 4, pp. 1195–1198, 2008. View at Publisher · View at Google Scholar · View at Scopus
- M. Hashimoto and M. Katakura, “Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat—a metabolic syndrome rat model,” Medical Gas Research, vol. 1, article 26, 2011.
- K. Xie, Y. Yu, Y. Pei et al., “Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release,” Shock, vol. 34, no. 1, pp. 90–97, 2010. View at Publisher · View at Google Scholar · View at Scopus
- K. L. Xie, Y. H. Yu, Z. S. Zhang et al., “Hydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model,” Shock, vol. 34, no. 5, pp. 495–501, 2010.View at Publisher · View at Google Scholar · View at Scopus
- X. X. Ni, Z. Y. Cai, D. F. Fan et al., “Protective effect of hydrogen-rich saline on decompression sickness in rats,” Aviation Space and Environmental Medicine, vol. 82, no. 6, pp. 604–609, 2011.View at Publisher · View at Google Scholar · View at Scopus
- H. Kawasaki, J. Guan, and K. Tamama, “Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials,” Biochemical and Biophysical Research Communications, vol. 397, no. 3, pp. 608–613, 2010. View at Publisher · View at Google Scholar · View at Scopus
- L. R. Qian, F. Cao, J. Cui et al., “Radioprotective effect of hydrogen in cultured cells and mice,”Free Radical Research, vol. 44, no. 3, pp. 275–282, 2010. View at Publisher · View at Google Scholar · View at Scopus
- L. R. Qian, B. L. Li, F. Cao et al., “Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage,” Nuclear Technology and Radiation Protection, vol. 25, no. 1, pp. 23–29, 2010. View at Publisher · View at Google Scholar · View at Scopus
Research Articles
DRINKS WITH ALKALINE NEGATIVE OXIDATIVE REDUCTION POTENTIAL IMPROVE EXERCISE PERFORMANCE IN PHYSICALLY ACTIVE MEN AND WOMEN: DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, CROSS-OVER TRIAL OF EFFICACY AND SAFETY
Sergej M. Ostojić1, 2, Marko D. Stojanović1, 2, Julio Calleja-Gonzalez 2, 3, Miloš D.Obrenović 2, Dragoljub Veljović1, Bojan Medjedović1,
Kristina Kanostrevac1, Mirjana Stojanović1 & Boris Vukomanović2 1 Faculty of Sport Sciences & Tourism, Novi Sad, SERBIA. 2Center
for Health, Exercise & Sport Sciences, Belgrade, SERBIA. 3Faculty of Sport Sciences, University of the Basque Country, ESPANA.
Abstract
In the current study we tested the hypothesis that an acute (7 days) intake of an alkaline negative oxidative reduction potential formulation
(NORP) drink would reduce the rate of blood lactate accumulation during and after exercise, increase time to exhaustion, increase serum buffering capacity and not increase prevalence of adverse effects as compared to the control drink. Eleven participants (9 men and 2 women) met the criteria to take part in the study. Participants were randomized in a double-blind, cross-over design to receive the control and the
NORP drinks within two single-week periods to study the efficacy of the NORP drink (at a dose of 1 L per day by oral administration). The NORP drink was supplied in bottles containing 2 g NORP, 6 g sucrose, 1-2 mg sodium per dose. The control drink was identically supplied and formulated except that it contained no NORP. Exercise testing was performed using a treadmill based ramp protocol. Blood glucose or
total antioxidant capacity were not affected by supplementation (p > 0.05) while serum bicarbonates were significantly higher after the NORP trial (p < 0.05). Critical HR at the velocity of 8.1 mph during the test was significantly lower in NORP as compared to the
control drink trial (p < 0.05). Blood lactate sampled at velocity 8.1 mph during the test was significantly lower in the NORP group (p < 0.05). No athletes reported any vexatious side effects of supplementation. It seems that NORP supplementation could have
a beneficial effect on human performance during maximal exercise.
HR-Heart Rate *NORP –Negative Oxidation-Reduction Potential
The drink was made using the active ingredient (patent-pending) in Recovery HydroFx.
ORIGINAL RESEARCH
Hydrogen-rich water affected blood alkalinity in physically active men
Sergej M. Ostojic, MD, PhD *, Marko D. Stojanovic, PhD
Center for Health, Exercise and Sport Sciences, Stari DIF, Belgrade, Serbia
* Corresponding author Full. Prof. Sergej M. Ostojic, MD, PhD
Exercise Physiology Laboratory, Center for Health, Exercise and
Sport Sciences Stari DIF, Deligradska 27, Belgrade 11000, Serbia
Abstract
Possible appliance of effective and safe alkalizing agent in the treatment of metabolic acidosis could be of particular interest to humans
experiencing an increase in plasma acidity, such as exercise-induced acidosis. In the present study we tested the hypothesis that the daily oral
intake of 2 L of hydrogen-rich water (HRW) for 14 days would increase arterial blood alkalinity at baseline and post-exercise as compared to the placebo. This study was a randomized, double blind, placebo-controlled trial involving 52 presumably healthy physically active male volunteers. Twenty-six participants received HRW and 26 a placebo (tap water) for 14 days. Arterial blood pH, partial pressure for carbon dioxide (pCO2),
and bicarbonates were measured at baseline and post-exercise at the start (day 0) and at the end of the intervention period (day 14). Intake of HRW significantly increased fasting arterial blood pH by 0.04 (95% confidence interval; 0.01 - 0.08; P < 0.001), and post-exercise pH by 0.07 (95% confidence interval; 0.01 -0.10; P = 0.03) after 14 days of intervention. Fasting bicarbonates were significantly higher in the HRW trial after the administration regimen as compared to the pre-administration (30.5 } 1.9 mEq/L vs. 28.3 } 2.3 mEq/L; P <0.0001). No volunteers withdraw before the end of the study and no participant reported any vexatious side effects of supplementation. The results support the hypothesis that HRW administration is safe and may have an alkalizing effect in young physically active men.
Proudly powered by Weebly